BHLHE40 and neoplasm: Then, we conducted SCENIC analysis to explore the transcriptional regulation driving the acquisition of the cholesterol-related Tumor-Modifying state in neutrophils [8] which revealed activation of BHLH family transcription factors (BHLHE40, ETV5, OLIG2, and SREBF1) within the Neu-T-CCL3 cluster (Figs. 3D, 3E, S4A, and S4B).