R-carvedilol is an enantiomer that limits the open-time of the endoplasmic reticulum (ER) ryanodine receptor type 2 (RyR2) calcium channel, likely has anti-oxidant properties like the racemic mixture, and corrects cognitive performance decline and neuronal hyperactivity in experimental models that are genetically engineered to mimic hallmark AD neuropathologies [7, 26, 59–63, 65, 67, 68, 72–74]. The gene discussed is RYR2; the disease is Alzheimer disease.