FZD7 and metastatic neoplasm: IHC analysis in primary tumors from patients diagnosed with HGSOC (stage: 3 + 4, grade: 3) revealed increased Fzd7 and active-p-ILKSer246 levels compared to corresponding adjacent normal ovarian epithelium (Fig. 4E), both Fzd7 and p-ILKSer246 staining was greatest in metastatic tumors (Fig. 4E and Tables S4 and S6).