We conducted whole exome sequencing of 137 children with hypopituitarism [34], and we reported two cases with variants in MORC2 and SETD5, the human orthologs of the IMPC candidate gene Morc2a and Setd5. The first patient carries a heterozygous variant in MORC2 (ENST00000397641.8): c.683C > T (p.Thr228Met) (rs774960940), which we consider likely pathogenic by four American College of Medical Genetics and Genomics (ACMG) reporting criteria (PM1, PM2, PP2, PP3) [7]. This evidence concerns the gene MORC2 and hypopituitarism.