Similarly, our previous single-cell genomics study deciphering features of drug resistance directly in ETV6-RUNX1 ALL patients during induction chemotherapy [23] demonstrated that although the diagnostic blasts matched a pro-B-like cell state, the persisting leukemic cells at day 15 are re-programmed towards a pre-B TF activity state. This evidence concerns the gene ETV6 and acute lymphoblastic leukemia.