Alternatively, perturbations in the epigenetic control that are a hallmark of KMT2A-r leukemias, such as the increased transcriptional variability reported upon histone acetyltransferase KAT2A loss in KTM2A-r acute myeloid leukemia [37], may facilitate stochastic cell diversification upon stress or injury. This evidence concerns the gene KMT2A and leukemia.