Supporting this, AZD1775 treatment did not alter RUNX1 mRNA expression levels in RS4;11 cells or in other B-ALL cell lines (Additional file 1: Fig. S5d), but increased RUNX1 protein ubiquitination upon proteasomal inhibition (Fig. 5b). The gene discussed is RUNX1; the disease is precursor B-cell acute lymphoblastic leukemia.