INS and vascular disorder: In the multivariable logistic regression analysis, female sex [p<0.001; OR 1.62 (95% CI 1.22–2.16)], BMI ≥ 30 [p<0.001; OR 2.04 (95% CI 1.42–2.93)], insulin-treated DM [p<0.001; OR 2.13 (95% CI 1.58–2.85)], peripheral vascular disease [p = 0.028; OR 1.59 (95% CI 1.05–2.42)] and direct oral anticoagulants (DOACs) [p = 0.015; OR 1.98 (95% CI 1.13–3.45)] were independently associated with any LWI (Table 3).