REN and renal cell carcinoma: In our high risk group, the completion and coalescence cascades, cycline and cycline receptor were significantly activated.Erythropoietin (EPO) protein deficiency independently predicts poor RCC prognosis, while intracellular renin (REN) deficiency is an unfavorable prognostic predictor of disease-free survival (DFS) in ccRCC patients, which is associated with venous invasion and high-grade tumor [35, 36].