Similarly, higher sPD-1 correlated with increased tumor invasion in patients with renal cell carcinoma [58] and with a larger tumor size and the presence of cervical lymph node metastasis in patients with differentiated thyroid carcinoma [56]; however, sPD-1 did not correlate with Gleason scores in patients with prostate cancer [59]. The gene discussed is HOXD13; the disease is prostate carcinoma.