Similarly, higher sPD-1 correlated with increased tumor invasion in patients with renal cell carcinoma [58] and with a larger tumor size and the presence of cervical lymph node metastasis in patients with differentiated thyroid carcinoma [56]; however, sPD-1 did not correlate with Gleason scores in patients with prostate cancer [59]. This evidence concerns the gene HOXD13 and hereditary clear cell renal cell carcinoma.