The Algarve is the region with the second highest HIV infection incidence in recent years, after the AML [25]; approximately 85% of cases of VL diagnosed in PLWH occurred in the setting of CD4 cell counts < 200/μl and, according to the most current data, 37.9% of PLWH are still diagnosed at this stage [25]. Here, CD4 is linked to acute myeloid leukemia.