Exploring the MILE dataset, a large dataset of AML showed no significant difference in the expression of SENP1 in bone marrow mononuclear cells of normal and AML patients (Figure.S2C); however, we found that SENP1 mRNA expression was significantly upregulated in AML patients with adverse prognosis (Figure.S2D). The gene discussed is SENP1; the disease is acute myeloid leukemia.