In the adjusted multivariate logistic model, Growth hormone-secreting pituitary tumor subtype (OR = 2.954, 95% CI: 1.139 ~ 7.661, P = 0.026), deviated nasal septum (OR = 5.438, 95% CI: 2.091 ~ 14.142, P = 0.001), chronic rhinosinusitis (OR = 2.736, 95% CI: 1.027 ~ 7.285, P = 0.044) and history of hypertension (OR = 3.089, 95% CI: 1.205 ~ 7.915, P = 0.019)were identified as independent risk factors for delayed epistaxis after ETPTR. Here, GH1 is linked to pituitary tumor.