CD8A and neoplasm: Additionally, more CD8+ cells were noted in high HLA-DR expressing samples (median 62.29 cells per mm2 for high HLA-DR+ samples vs. median 2.05 cells per mm2 for low HLA-DR+ samples, p-value < 0.0001) This indicates that increasing HLA-DR expression in ONB tumor cells may help to drive T cell trafficking into the ONB tumor parenchyma.