CXCL9 and neoplasm: In our cohort, samples containing more CD8+ T cells, ≥ 10 cells per mm2, in the tumor parenchyma contained more CXCL9+ and CXCL10+ tumor cells, indicating that tumor cell expression of these key chemokines may also drive tumor parenchymal infiltration of CD8+ T cells (Fig. 5C).