The IVW analysis results reveal that HMGCR inhibitors (OR [95%CI] = 0.567 [0.315, 0.820], p < 0.001) and PCSK9 inhibitors (OR [95%CI] = 0.450 [0.036, 0.865], p < 0.001) both significantly reduce the risk of CHD. The gene discussed is HMGCR; the disease is coronary artery disorder.