IL4 and lung disorder: Interestingly, it is well-recognized that the M2 macrophages polarization are induced by the T-helper-2 (Th2) cytokines IL-4 and IL-13 which are elevated in several lung diseases involving fibrosis, and TH5487 has been demonstrated to cause a considerable decrease of IL-4 and IL-13, as well as reduced macrophages, in asthma mice (Tanner et al. 2022).