ACTA1 and pulmonary fibrosis: As shown in Fig. 2A, B that the damaged lung structure and the excessive collagen deposition following BLM induction were partly attenuated by TH5187 treatment, and the BLM-elevated Collagen I and α-SMA expression was also reduced following TH5187 treatment, demonstrating that TH5487 administration alleviated pulmonary fibrosis.