By recognizing specific phosphorylation motifs and interacting with target proteins, 14-3-3 proteins participate in a variety of intracellular processes, regulate the subcellular localization of target proteins [50], and act as a stress-adaptive signaling hub in cancer cells that governs critical processes, including apoptosis, cell cycle progression, autophagy, glucose metabolism, and cell motility [51, 52]. Here, YWHAQ is linked to cancer.