This study revealed that several factors, including the distance from the esophagogastric junction (EGJ) to the distal end of the tumor (> 4.0 cm), preoperative carcinoembryonic antigen (CEA) ( +), pT4 stage, and HER-2 ( +), independently correlated with LPLN metastases in patients who underwent TG for Siewert type II and III AEG. This evidence concerns the gene ERBB2 and neoplasm.