Carcinoembryonic antigen (CEA), pathological T (pT) stage, lauren type, distance from the esophagogastric junction (EGJ) to the distal end of the tumor, pathological subtype, vascular invasion, nerve invasion, HER-2 expression, and CD34 levels exhibited significant statistical differences (P < 0.05) between the two groups (Supplemental Tables 1, 2 and 3). The gene discussed is ERBB2; the disease is neoplasm.