Independent risk factors for LPLN metastases in Siewert type II and III AEG patients undergoing TG included the distance from the EGJ to the distal end of the tumor (> 4.0 cm) (OR 4.619, P = 0.019), CEA positivity (OR 2.806, P = 0.039), pT4 stage (OR 2.944, P = 0.046), and HER-2 positivity (OR 3.177, P = 0.028). This evidence concerns the gene ERBB2 and neoplasm.