Following this analysis, preoperative CEA positivity (OR 3.119, P = 0.006), tumor distance from the EGJ (> 4.0 cm) (OR 4.470, P = 0.003), tumor differentiation (OR 4.620, P = 0.006), pT4 stage (OR 4.020, P = 0.004), presence of vascular invasion (OR 2.882, P = 0.017), nerve invasion (OR 2.968, P = 0.024), HER-2 positivity (OR 3.717, P = 0.002), CD34 positivity (OR 3.678, P = 0.034), and lauren classification (P = 0.022, 0.020, 0.012, respectively) emerged as risk factors for LPLN metastases in Siewert type II and III AEG patients who underwent TG. The gene discussed is ERBB2; the disease is neoplasm.