In summary, resveratrol facilitates TSC2 recruitment to the lysosome, inhibiting mTORC1 pathway and improving the mitochondrial turnover, contributing to pancreatic β cell homeostasis in a TSC2 and SIRT-1 dependent manner, which is crucial in avoiding metabolic disorders such as type 2 diabetes. The gene discussed is SIRT1; the disease is type 2 diabetes mellitus.