Our previous paper showed the potential of nanosecond pulsed electric field (nsPEF) in the reduction of the multi-drug resistance effect in pancreatic cancer cells via the release of P-GP (P-Glycoprotein / MDR1) and LRP (Low-density lipoprotein receptor-related protein) from the cells in the extracellular microvesicles20. This evidence concerns the gene ABCB1 and pancreatic neoplasm.