Scrutiny of mRNA expression from The Cancer Atlas Genome (TCGA) and ONCOMINE datasets confirmed significant elevation of Trx1 and TrxR1 in NSCLC subsets lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) (Fig. 1c and Supplementary Fig. S1a, b). This evidence concerns the gene TXNRD1 and lung adenocarcinoma.