SH2D3C and infection: Nsp3 of betacoronaviruses (SARS-CoV-1, MERS-CoV and MHV) was previously localized to the convoluted membranes and to the DMV membranes using immuno-EM3,4,57,58 and cryo-ET25; however, these studies were limited to early-mid infection at 8-12 hpi.