RUNX1 and acute myeloid leukemia: Main gene mutations in de novo BCR::ABL1+ AML were RUNX1 (n = 5), ASXL1 (n = 4), NPM1 (n = 3), BCOR (n = 2), TET2 (n = 2) and WT1 (n = 2) (Fig. 1B) and no patients had detectable ABL1 mutations.