Specifically, the increase in lymphocyte populations was positively associated with the MA−4: SPP1+ FABP5+ intermediate class, whose inflammatory cytokines/chemokines production may be responsible for lymphocyte homing100, and negatively associated with MA−2: LYVE1+ TIMD4+ TRM, whose gene markers were found more often expressed in synovial TRMs from healthy and remission RA than active RA patients13 (Fig. 8b). This evidence concerns the gene TIMD4 and rheumatoid arthritis.