CXCL12 and rheumatoid arthritis: In the SA−0: CXCL12+ HLA-DRhi sublining chromatin class, we found TEAD152 (padj = 2.86e-52; Fig. 3c) and STAT1/3 TF motif enrichments (padj = 3.34e-37, 4.27e-38, respectively; Fig. 3c), with the latter likely regulating the JAK/STAT pathway responsible for the proinflammatory cytokine activation central to RA clinical activity9,53.