We generated a multiome dataset of sorted RA PBMC subsets via fluorescence-activated cell sorting (FACS) of four populations spanning two chromatin classes and four transcriptional states: CD4+CD127−CD25hi Treg, CD4+CD127−CD25int Treg, CD4+CD25−PD1+CXCR5+ TFH, and CD4+CD25−PD1+CXCR5− TPH (Supplementary Fig. 15a). Here, CD4 is linked to rheumatoid arthritis.