Specifically, the increase in lymphocyte populations was positively associated with the MA−4: SPP1+ FABP5+ intermediate class, whose inflammatory cytokines/chemokines production may be responsible for lymphocyte homing100, and negatively associated with MA−2: LYVE1+ TIMD4+ TRM, whose gene markers were found more often expressed in synovial TRMs from healthy and remission RA than active RA patients13 (Fig. 8b). The gene discussed is SPP1; the disease is rheumatoid arthritis.