Notably, we found that YTHDF3 protein levels were downregulated in ZDHHC20-KO pancreatic cancer cells, and the knockdown of HSC70 or LAMP2A reversed the effects of ZDHHC20 deficiency on YTHDF3 protein levels in ZDHHC20-KO cells (Fig. S8H, I). This evidence concerns the gene ZDHHC20 and familial pancreatic carcinoma.