Knockdown of YTHDF3 inhibited the progression of pancreatic cancer and counteracted and even reversed the promoting effects of ZDHHC20 overexpression on tumor growth and invasion in vitro and in vivo (Figs. 4K–M and S6D–G), implying that YTHDF3 may play a crucial role in mediating the oncogenic capacity of ZDHHC20 in pancreatic cancer. This evidence concerns the gene YTHDF3 and familial pancreatic carcinoma.