Phosphorylation, ubiquitination, and palmitoylation modifications have been reported for other ZDHHCs41,42, and we conjecture that post-translational modifications of the ZDHHC20 protein in pancreatic cancer may lead to the significance of the mRNA-protein expression difference and may further amplify its carcinogenicity. The gene discussed is ZDHHC20; the disease is familial pancreatic carcinoma.