Based on a recent report in Ewing sarcoma,54 we designed a series of putative loss-of-interaction mutants for RUVBL1 (RUVBL1Δ94-118, RUVBL1Δ102-107, RUVBL1K108A) and tested their interaction in co-immunoprecipitation experiments in KPC cells. This evidence concerns the gene RUVBL1 and Ewing sarcoma.