CDKN2A and neoplasm: Finally, inhibition of RUVBL1 by CB-6644 for 5 days caused infiltration of CD3-positive immune cells in tumours induced by a second KPC cell line (9172) and murine PDAC cells driven by the mutations KrasG12D/+ and Cdkn2a−/− (24031), indicating that RUVBL1-mediated immune evasion is not restricted to the initially used KPC cell line (online supplemental figure S7G,H).