Overexpression of Cdkn2b in Xenopus microphthalmia models correlated with reduced cell proliferation due to cell cycle misregulation (Aldiri et al., 2013), and upregulation of CDKN2A and CDKN2B reduces proliferation in the developing retina (Dimaras et al., 2008). The gene discussed is CDKN2B; the disease is microphthalmia.