RYR1 and muscular dystrophy: Aberrant (generally increased) modification of RyR1 has been reported in multiple mouse models of muscle pathophysiology [2], notably muscular dystrophies and central core diseases [5], but the functional roles of post-translational modification of RyR1 in normal physiology remain under-characterized and controversial, reflecting at least in part the lack of genetic models in which sites of modification are altered.