Although aberrant S-nitrosylation of multiple unidentified sites has been associated with dystrophic diseases, malignant hyperthermia and other myopathic syndromes, S-nitrosylation in physiological situations is reportedly specific to a single (1 of ~100) Cys in RyR1, Cys3636 in a manner gated by pO2. Here, RYR1 is linked to Malignant hyperthermia.