INS and type 2 diabetes mellitus: Insulin metabolism, fenofibrate action in type 2 diabetes (T2D), oxidative stress in T2D, adiponectin pathogenesis in T2D, regulation of metabolism and role of adiponectin, transcription of HIF1 targets, TCA cycle, and cytoskeleton remodeling were the common processes observed in all samples, indicating that the characteristic of adipose tissue is mimicked by differentiated adipospheres, demonstrating their ability to represent the adipose tissue.