Recent studies have shown that the NLRP3/ASC/Caspase-1/IL-1β/IL-18 of cell pyroptosis signaling pathway-mediated inflammatory response promotes the pathological process of a variety of kidney diseases, and Caspase-11 activates Caspase-1 and stimulates the maturation of pro-IL-1, resulted in the promotion of renal fibrosis [50], suggesting that NLRP3-mediated inflammatory response and cellular pyroptosis may be involved in the occurrence and development of renal fibrosis. This evidence concerns the gene NLRP3 and renal fibrosis.