CD4 and tuberculosis: Table 2 shows their baseline demographic and clinical characteristics. The median age was 40 years (range: 18–82 years) and 52% were female. Overall, 26% had a history of prior TB treatment, 5% had a history of prior ART and 78% were on ART at the date of consent. Median CD4 count was 369 cells/μl. Of the 1637 participants, 296 (18%) were classified as positive for TB by eMRS and 1341 (81.9%) as negative for TB. Table 3 in S5 File shows the demographic and clinical characteristics of the study participants stratified by country.