Additionally, a recent study demonstrated that a common missense variant (G78R, rs1859788) of PILRA reduces the binding of PILRA to various ligands, including HSV-1 glycoprotein B, thereby decreasing the risk of HSV-1 infection, which is considered an environmental protect factor for Alzheimer’s Disease [35]. The gene discussed is PILRA; the disease is early-onset autosomal dominant Alzheimer disease.