The negative association between aSAH and antidiabetic medications may reflect the lower incidence of aSAH among diabetics [38, 39], while the positive association between aSAH and antihypertensives (e.g. ACE-inhibitors, calcium channel blockers) may reflect the higher incidence of aSAH among people with hypertension [32]. This evidence concerns the gene ACE and Hypertension.