RPS19 and Diamond-Blackfan anemia: For example, the RPS19 gene is frequently mutated in DBA patients, and its knockdown leads to global translational defects in several cell types including both hematopoietic and non–hematopoietic-origin cells (HeLa, embryonic stem cells, different erythroid cell lines, and progenitor cells) (6, 7, 24–27).