To identify epigenetic modifying complexes that may contribute to the MYCN oncogenic program in neuroblastoma, we calculated CRISPR-Cas9 dependency scores for individual genes in MYCN-amplified neuroblastoma cell lines found in the DepMap Project (n = 27; table S1) as compared to dependency scores for all other non-neuroblastoma solid tumor cell lines (n = 944). Here, MYCN is linked to neuroblastoma.