APP and early-onset autosomal dominant Alzheimer disease: Moreover, the known Alzheimer’s disease genetic risk variants are contributing differently to molecular pathways,18,21,22 where each pathway in turn will exercise differential effects on the Alzheimer’s disease biomarkers, including markers for vascular pathology.37 Therefore, a pathway PRS comprising only genes associated with the regulation of the amyloid precursor protein catabolic process (e.g. Gene Ontology term GO:1902991) might contribute significantly to the conversion from A−T− to A+T−.