BIN1 mediates Alzheimer’s disease risk by modulating tau pathology,66 and BIN1 risk variants increase tau PET (but not amyloid PET)67 in an amyloid-dependent fashion.68 Our observations of an amyloid-dependent effect of the PRS align with these earlier single-gene studies. The gene discussed is BIN1; the disease is early-onset autosomal dominant Alzheimer disease.