MAPT and Lewy body dementia: CoA’s roles in protein modification and antioxidation may play a key role in tauopathies such as AD and DLB, with the CoAlation of tau protein in AD brain samples being observed to protect against the H2O2-induced dimerization of tau [16]; a loss of CoA as a result of pantothenic acid deficiency may lead to the loss of this protective mechanism.