In addition, it was found that antagonizing ferroptosis by enhancing the activity of glutathione peroxidase 4 (GPX4) effectively improved the neurological function of mice with ischemia/reperfusion in the middle cerebral artery, whereas the prognosis of stroke was worsened due to increased ferroptosis after weakening GPX4 function [16]. The gene discussed is GPX4; the disease is Stroke.