Therefore, we speculate that these five specific immunophenotypes, including CD4 +T cell %leukocyte, CD127 on CD45RA − CD4 not regulatory T cell, CD45 on CD33 + HLA DR + WHR, CD33 on basophil, and Monocyte AC, may mediate the interaction between the gut microbiota and MDS. Here, PTPRC is linked to myelodysplastic syndrome.