SIRT6 and cancer: Given SIRT6’s involvement in pivotal pathological processes across various cancer types, it was selected as a putative target gene for miR-34a-5p.To verify whether SIRT6 is indeed a target of miR-34a-5p, we synthesized the 3′UTR of SIRT6 containing the possible miR-34a-5p binding sites with (wide-type) or without (mutant) mutations and inserted them into luciferase reporter vectors.