We selected the top 32 deregulated genes (OSCC vs. HC: 5–24 log2 fold‐change; padj <0.0001) and identified their biological roles, such as tumor suppressor, cell proliferation, and cell–cell adhesion and migration function (Table S7A); pathway analysis (by IPA) revealed that three out of the top 32 deregulated genes—TNC (tenascin‐C), MMP‐10, and TP63 (OSCC vs. HC: 5–8 log2 fold‐change; padj <0.05; Figure 3A), associated with canonical pathways, such as Tumor Microenvironment Pathway (Figure S1; Table S8A). This evidence concerns the gene MMP10 and neoplasm.