Also, pathways analysis revealed that saliva miR‐1273 h‐5p and miR‐1180‐3p can interact with the discovered saliva mRNA profiles to regulate PI3K/AKT/mTOR pathway, the oncogene MAP3K8, which can activate downstream molecules including cancer‐related MEK, ERK, and JNK, NF‐κB, TNF, and IL‐1,36, 40 as well as BCL2 pathways.37 This evidence concerns the gene AKT1 and cancer.