Because RELA (p65) is a central factor in cancer that based on our prior preclinical and clinical data plays an important role in the progression of HNC,1, 3, 4, 43 and according to our data presented here, RELA(p65) was found one of the most altered genes in serum of OSCC versus HC (>25 fold changes, p < 0.05), we selected this gene to verify our sequencing data by qPCR and IHC in tumor tissue. Here, RELA is linked to cancer.