Finally, we present data from pathway analyses that showed that saliva and serum miRNAs can interact with mRNA profiles through the PI3K/AKT pathway, as well as their predicted targets, and suggested miR‐7704, miR‐1273 h‐5p, miR‐1180‐3p, miR‐499‐5p, and miR‐23a‐5p, for future therapeutic explorations or candidate biomarkers of the effectiveness of targeted therapy for oral cancer. The gene discussed is AKT1; the disease is lip and oral cavity carcinoma.