Liu et al. [55] believed that OTUB2 is overexpressed in ESCC and can directly stabilize and interact with YAP1/TAZ through SUMO, leading to the stimulation of YAP1/TAZ expression and activation of downstream target genes such as CTGF and CYR61, thereby promoting tumor cell progression. Here, YAP1 is linked to esophageal squamous cell carcinoma.