OAS1 and viral infectious disease: A recent example demonstrating the importance of protein prenylation for viral infection resulted from studies of OAS1 gene splice variants, which concluded that humans expressing a prenylated variant of the Oas1 protein had higher innate antiviral protection against Sars-CoV-2 than those expressing the non-prenylated protein (Soveg et al., 2021; Wickenhagen et al., 2021).