KEGG pathway enrichment analysis suggested that the 40 candidate target genes were mainly enriched in pathways of neurodegeneration‐multiple diseases, AGE‐RAGE signalling pathway in diabetic complications and Fluid shear stress and atherosclerosis, and BDNF was also significantly enriched in the pathways of neurodegeneration‐multiple diseases (Figure 2G). This evidence concerns the gene RENBP and atherosclerosis.