DBI and liver disorder: We chose to analyze the effects of OCs vs spiomet on organokines recently related to MAFLD, such as meteorin-like protein (METRNL), recently reported to be related to liver injury (30); fibroblast growth factor-21 (FGF21), a hepatokine with enhanced expression in liver disease, potentially protective against systemic dysmetabolism in MALFD (31), and diazepam-binding protein-1 (DBI, also named acyl CoA-binding protein), whose blockage has been reported to improve MAFLD in recent experimental settings (32).