METRNL and polycystic ovary syndrome: To our knowledge, this is the first study in PCOS adolescents exploring the effects of two randomized treatments on the circulating concentrations of DBI, a multifunctional protein that mediates broad hepatoprotective effects (41), and METRNL, a regulatory protein involved in adipose tissue plasticity, inflammation, and cardiac function (42), recently identified as a potential hepatokine (30).