NLRP3 and type 1 diabetes mellitus: Interestingly, although we could not detect any signal in SC cytoplasm, IF data revealed a peculiar NLRP3 localization in both control and T1D testis, indeed it was associated with the developing acrosome system in the control, assuming a dot-shaped conformation in round SPT while, in T1D, its extension and signal intensity were increased, particularly in SPT, where a clear nuclear NF-κB signal was also observed.