In the testis of T1D rats, the intensity of the two signals showed an opposite behavior since it was higher for NRF2 (p < 0.001; Figures 8J, K) and weaker for SIRT1 (p < 0.05; Figures 8J, L), particularly in SPC (arrowhead; Figure 8J) and SPG (arrow; Figure 8J), respectively. Here, SIRT1 is linked to type 1 diabetes mellitus.