↑ mindfulness state (TMS), quality of life (SF-36),↓ perceived stress (PSS-10), overall psychological distress, depression and anxiety on BSI-18, fasting glucose,Improved sleep (PROMIS Sleep-Related Impairment T-score), PANAS Negative and positive Affect Scores,↔ weight, BMI, WC, BP, fasting insulin, HOMA-IR, Lipid profile, HbA1c, Salivary cortisol and HsCRP.No adverse event occurred. This evidence concerns the gene INS and Abnormal emotional state.