↓ mFG score, LH, LH/FSH, AMH, Total testosterone, FI, FBG, HOMA-IR, TC, TG, LDL, VLDL, TC/HDL, trait anxiety (STAI)↑ HDL, menstrual cycle frequency and quality of life (PCOSQ)↔ weight, BMI, WC, WHR, FSH, Prolactin, and state anxiety.Adverse events not reported. Here, PLOD1 is linked to anxiety disorder.