For example, lncRNA LITATS1 inhibits EMT in breast cancer and non-small cell lung cancer cells by promoting polyubiquitination and proteasomal degradation of TβRI 164; lncRNA LINP1 inhibits TGF-β1/Smad4-induced EMT and cell invasion in lung cancer cells 165. This evidence concerns the gene TGFB1 and breast carcinoma.