Inflammatory cytokines such as IL-1, IL-6 and IFN-γ can also cause metabolic disorders of liver cytochrome P450, affect the clearance rate of the body, prolong the action time of some antiviral drugs that prolong the QT interval, resulting in a marked extension of the QT interval in patients with COVID-19 and an increase in susceptibility to TdP (Figure 3C) 10, 62. The gene discussed is IL6; the disease is COVID-19.