This mechanism mediates the resistance of pancreatic cancer cells cultivated on COL11A1-coated plates to gemcitabine (Wang et al., 2021) and the resistance of ovarian cancer cells exposed to recombinant POSTN or co-cultured with POSTN-overexpressing fibroblasts to cisplatin (Chu et al., 2020). This evidence concerns the gene POSTN and familial pancreatic carcinoma.