CXCL12 and familial pancreatic carcinoma: Co-cultivation experiments involving ovarian, colorectal, and pancreatic cancer cells with CAFs or CAF supernatants have demonstrated a reduction in cisplatin- and gemcitabine-induced apoptosis, attributed to CAF-derived CXCL12 (Zhang et al., 2015; Morimoto et al., 2016; Wei et al., 2018; Zhang et al., 2020; Jiang et al., 2023).