In addition to titin, RBM20 controls the splicing fates of crucial cardiac genes such as CamkIIδ, and RyR2, such that RBM20 gene mutation causes mis-splicing events of these cardiac genes, resulting in early onset dilated cardiomyopathy (Guo et al., 2012; van den Hoogenhof et al., 2018). The gene discussed is RBM20; the disease is dilated cardiomyopathy.