For example, AAV9-mediated expression of the circRNA circFndc3b was found to reduce pathological cardiac remodeling in a mouse myocardial infarction model, and the proposed mechanism is via circRNA binding and sponging of the RBP FUS to reduce FUS binding to endogenous targets (Garikipati et al., 2019). The gene discussed is FUS; the disease is myocardial infarction.