AMOTL1 and cardiovascular disorder: An interesting observation was done by Ragni et al. [30] who showed that Angiomotin-like 1 (Amotl1) upon interaction with its partner, Fat4, a cadherin, can act as a inhibitor or a facilitator of Yap, and thus affecting thickness of the ventricular walls, further pointing out possibilities for studying the mechanism in cardiovascular diseases, including familial DCM.